Perfect Beauty Life® Sun Blocker 2017-11-14T01:43:52+00:00

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Beauty from Inside Out

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Key Ingredients
Scientific Summary

External beauty treatments alone are no longer enough, because natural beauty comes from inside out. The reason for this is easy to explain. The deeper layers of the skin have a crucial influence on our appearance. Our skin can only look radiant when these layers are well nourished. This is why a good supply of essential nutrients from inside out plays a decisive role in beauty and in the appearance of the skin in particular.

The Perfect Beauty Life® Range are brand new Nutricosmetic products with unique and innovative formulations containing the specially designed Lycolignol® -Complex clinical study in Germany, supervised by dermatologists and nutritionists. It is a scientific break-through in the beauty from inside out market.

Specially designed Lycolignol®-Complex:
The Lycolignol® -Complex is a unique high-quality blend of three ingredients. It combines special grades of flaxseed extract, green tea extract and lycopene-rich tomato extract.

It has proven antioxidant properties and protects the skin against the negative effects of free radicals.

  • Lycolignol® -Complex in the same composition as Perfect Beauty Life® Anti Age, which is clinically tested and proven in Germany, supervised by dermatologists and nutritionists.
  • Unique and innovative compositions
  • Premium raw materials (partially EFSA approved health claims)
  • Special visual appearance due to pearl effect colours
  • Dosage form: soft gelatin capsule
  • Size: 9 minims
  • Form: oval
  • Recommended dose: 2 capsules daily with meals

Prepare your skin for the sun

Protects the skin before and during the sun exposure. Lycolignol® -Complex combined with argan oil, astaxanthin, biotin and grape seed extract.

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The skin needs protection from the sun, in particular in the summer months. Although the sun is vital to life, too much UV radiation damages our skin and encourages the formation of free radicals. This subjects skin cells to stress and can lead to signs of ageing. The high-quality ingredients in Perfect Beauty Life® Sun help to prepare the skin for exposure to sunlight. Argan oil is believed to have strong anti-oxidative properties, especially those that have an affect on the skin1 . The carotenoid astaxanthin can prevent UV damage when taken internally2 . Together with polyphenol-rich grape seed extract, it promotes a healthy skin from inside out and provides protection against antioxidants.

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  1. Secondary metabolites of the argan tree (Morocco) may have disease prevention properties; African Journal of Biotechnology Vol. 4 (5), pp. 381-388, May 2005.
  2. Natural Astaxanthin: King of the Carotenoids: Copyright 2007 by Cyanotech Corporation
  3. N. Shimidzu, M. Goto and W. Mili. 1996

Key Ingredients

Lycolignol®-Complex: Has proven antioxidant properties and protects the skin against the negative effects of free radicals, clinical study in Germany, supervised by dermatologists and nutritionists.
Argan oil: well known for its cosmetic, pharmaceutical and nutritional virtues and traditionally well known for its cardioprotective and antioxidant properties. It used in the treatment of skin infections as well as a food and as a food ingredient, it has been applied to the skin for centuries. Argan oil is of interest in cardiovascular risk prevention due to its fat composition and antioxidant compounds and rich in minor compounds such as phenolic compounds, plant sterols and tocopherols and these compounds have antioxidant effects.
Astaxanthin: can improve skin condition and wrinkles, age spot size, elasticity and skin texture especially support skin structure during sun exposure. Supports healthy skin and anti-aging through cellular health, protects DNA and healthy immune function as well as supports healthy response to physiological stress.
Vitamin E: Contributes to the protection of cells from oxidative stress.

Vitamin C: Contributes to normal collagen formation and the normal function of skin. It also contributes to the protection of cells from oxidative stress.
Zinc: Contributes to the maintenance of normal hair, nails and skin. Contributes to the protection of cells from oxidative stress. Has a role in the process of cell division.
Copper: Contributes to normal hair and skin pigmentation. Contributes to maintenance of normal connective tissues. Contributes to the protection of cells from oxidative stress.
Grape seed extract: natural source of beneficial bioactive compounds. Vitis vinifera seed extract is a rich source of antioxidants such as catechins. oligomeric proanthocyanidins (OPC) could reduce reddening of the skin.It contains Anthocyanins, which contain naturally occurring antioxidants, which may help to protect against the damage caused by free radicals, as part of a healthy lifestyle.
Biotin: contributes to normal energy-yielding and macronutrient metabolism, maintenance of normal skin and hair.

Composition Amount per capsule % of NRV*
Argan oil 160 mg **
Lycolignol® -Complex 90 mg **
Vitamin C ♦ 60 mg 75
Vitamin E ♦ 6 mg 50
Zinc ♦ 2.5 mg 25
Copper ♦ 0.5 mg 50
Astaxanthin 1 mg **
Biotin ♦ 25 mcg 50
Grape seed extract 75 mg **

* NRVs: Nutrient Reference Values for the daily intake as defined in Regulation (EU) No. 1169/2011
** No NRVs defined
♦ Positive EFSA opinion avaiable (related to the ingredient not to the indication)

Stability study according to ICH guidelines

Stability tests have been performed on a long-term basis to determine an optimal shelf-life.

  • Climatic Zone II: 25 C / 60% RH, duration: 3 years
  • Climatic Zone III: 30 C / 65% RH, duration: 1 year
  • Climatic Zone IV: 40 C / 75% RH, duration: 6 months

Current stability results indicate a shelf life of 24 months

Special appearance

  • Dosage form: soft gelatin capsule
  • Size: 9 minims 750 mg per capsule
  • Form: oval
  • Colour: gold with shimmer
  • Recommended dose: two capsules daily
  • 1 softcap with main meals, twice a day for much better resorption to have higher bioavailability.
  • Optimum result will be seen in 90 days

The Science behind and mode of action of

Perfect Beauty Life® Sun – Prepare your skin for the sun
– Scientific Summary –

Exposure to sunlight can be enjoyable, but too much sunlight can be dangerous to the skin.  Overexposure to the sun’s ultraviolet (UV) radiation can cause immediate effects such as sunburn and long-term problems with the skin. They penetrate deep into the skin and damage cells. These cells are then at risk of becoming cancerous. You can’t feel UV damaging your skin and this happens even if the sun doesn’t feel hot. UV light is also an external oxidative stressor on the skin, and the level of generated free radicals depends on the UV dose. Sunlight consists of two types of UV radiation: UVA and UVB. Both radiation types contribute to freckling, skin wrinkling and the development of skin cancer.

Perfect Beauty Life® Sun is a particular combination of ingredients such as argan oil, astaxanthin, grape-seed extract and the specially designed Lycolignol®-Complex. Vitamin C and E, zinc, copper and biotin complete the formulation to protect the skin from sun damage.

Lycolignol®-Complex

Lycolignol®-Complex is a unique, high-quality blend of three ingredients. It combines special grades of flax-seed extract, green-tea extract, and also lycopene rich-tomato extract. This specially designed blend has been tested positive in a human clinical study. The antioxidant properties of the ingredients take care of the skin and help to catch the free radicals of the sun.

Argan Oil

Over the last 15 years, cosmetic argan oil, used either as a beauty oil or cosmetic ingredient, has become one of the most important substances in the dermo-cosmetic field.3

Traditionally, argan oil is well known for its treatment of skin infections. Argan oil is principally composed of mono-unsaturated (up to 80%) and saturated (up to 20%) fatty acids. As minor components, it contains polyphenols, tocopherols, sterols, squalene and triterpene alcohols.  Together with the mono-unsaturated fatty acids, these minor components are probably responsible for its beneficial effects.2  Remarkable properties of argan oil as evaluated by numerous laboratories are the restoration of the skin’s water-lipid layer and an increase in nutrients in the skin cells, moreover the stimulation of intracellular oxygen, the neutralization of free radicals and protection of the conjunctive tissue.1

Astaxanthin

Skin ageing, a combination of natural and environmentally induced processes, is predominantly caused by UV light from the sun. The results of the action of these UV rays are in seen in characteristic tissue alterations such as the degradation of collagen, the formation of visible fine lines and wrinkles4. They can also cause premature aging of the skin, dry skin, age spots and freckles. By preventing UV damage, skin can be protected from these conditions. And there is evidence that natural astaxanthin not only prevents UV damage from occurring, but may actually also help to reverse these external signs of ageing from the inside out.

Astaxanthin is an effective internal sunscreen that protects the skin from damage caused by exposure to UV light. This has been demonstrated in vitro in animal models as well as in a human clinical trials. In addition to its protective properties, there is evidence that astaxanthin may have curative properties for the skin and serve as an internal beauty supplement. It certainly appears that Astaxanthin has great potential as a sun supplement.5

Two human clinical studies were performed to show the cosmetic benefits of astaxanthin on human subjects. One was an open-label, non-controlled study involving 30 healthy female subjects for 8 weeks. Significant improvements were observed with oral supplementation and also topical application of astaxanthin. It showed improvements in regard to skin wrinkling, age-spot size, elasticity, skin texture, moisture content of the corneocyte layer and comeocyte condition. This may indicate that astaxanthin derived from Haematococcus pluvialis can improve skin condition in all layers, such as the corneocyte layer, epidermis, basal layer and dermis, by combining oral supplementation and topical treatment. Another randomized double-blind, placebo-controlled study involving 36 healthy male subjects for 6 weeks was performed. Crow’s feet wrinkles and elasticity, and trans epidermal water loss (TEWL) were improved after daily supplementation. Moisture content and sebum oil levels at the cheek zone showed strong tendencies to improve. These results suggest that astaxanthin derived from Haematococcus pluvialis may improve skin condition not only in women but also in men.6

Grape-seed Extract

The ultimate aim of protecting the skin against damage from sunlight is to prevent the consequences of the effects of UV radiation, such as oxidative stress. Providing antioxidants to the superficial skin layers by supplementation with nutrients may support the skin’s defenses, thereby protecting it against the harmful effects of UV light.7

Grapes – or the chemicals contained within them, especially the well-known oligomeric proanthocyanidin complexes (OPCs) – have long been considered as powerful antioxidants.8

OPCs are phytonutrients that belong to the polyphenol family of antioxidants and possess a high free-radical-scavenging activity. OPCs have also been shown to protect collagen and elastin from degradation by collagenases and elastases. The anti-inflammatory, antiallergicand anti-ageing properties attributed to OPCs are of particular interest in dermatology.7

Vitamin C

A cause-and-effect relationship has been established between the dietary intake of vitamin C and normal collagen formation. The European Food Safety Authority (EFSA) considers that the following wording reflects the scientific evidence: “Vitamin C contributes to normal collagen formation and the normal function of skin.” 9

Vitamin C functions physiologically as a water-soluble antioxidant and plays a major role as free-radical scavenger (Sadler et al., 1999; IoM, 2000). It is part of the antioxidant defense system, which is a complex network including endogenous and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects between the various components. The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of vitamin C and the protection of DNA, proteins and lipids from oxidative damage.9

Vitamin E

Vitamin E is also part of the antioxidant defense system, which is a complex network including both endogenous and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects among the various components. (Shils et al., 2006; IoM 2000). Reactive oxygen species (ROS) can damage molecules such as DNA, proteins and lipids if they are not intercepted by the antioxidant network, which includes free-radical scavengers such as antioxidant nutrients. The EFSA points out that a cause-and-effect relationship has been established between the dietary intake of vitamin E and protection of DNA, proteins and lipids from oxidative damage. The following wording reflects the scientific evidence: “Vitamin E contributes to the protection of cell constituents from oxidative damage”.10

Zinc

Zinc plays an essential structural, regulatory or catalytic role in many enzymes, and maintains the configuration of a number of non-enzymatic proteins. It also facilitates hormone and receptor binding at membrane and nuclear levels, and contributes to the integrity of biomembranes.  Consequently, zinc participates in gene expression and in the mechanism and control of major metabolic pathways involving proteins, carbohydrates, nucleic acids and lipids (SCF, 1993; DoH, 1991). Human zinc-deficiency symptoms include skin lesions such as changes in the regeneration of the skin (SCF, 2003; EVM, 2002, Cousins, 2006). The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of zinc and the maintenance of normal skin. The following wording reflects the scientific evidence: “Zinc contributes to the maintenance of normal skin” 11, and “Zinc contributes to the protection of cell constituents from oxidative damage”.12

Copper

Symptoms of severe copper deficiency include lack of collagen maturation. Copper is a cofactor of an extracellular enzyme called lysyl oxidase (LO), which is critical to the formation and functioning of connective tissue. The reaction of oxidative deamination of specific lysine residues in the extracellular matrix initiates the formation of cross-links that stabilize newly formed elastin and collagen (Linder and Hazegh-Azam, 1996).

The role of copper in the pigmentation of skin is related to the requirement of cuproenzyme tyrosinase (monophenol oxidase) for melanin synthesis. Mutational loss of this catalytic function leads to albinism (Arredondo and Nunez, 2005; Linder, 1991). The EFSA considers that the following wording reflects the scientific evidence: “Copper contributes to normal skin and hair pigmentation”.13

Biotin

Symptoms of biotin deficiency include a scaly (seborrheic), red (eczematous) skin which is reversible by administration of biotin (Mock, 2005). There is evidence that impaired fatty-acid metabolism secondary to reduced activities of the biotin-dependent carboxylases (especially acetyl CoA carboxylase) plays an aetiological role in the dermatological manifestation of biotin deficiency (Mock, 1991). The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of biotin and maintenance of normal skin and mucous membranes. The following wording reflects the scientific evidence: “Biotin contributes to the maintenance of normal skin and mucous membranes.” 14

Conclusion

Based on the scientific data and the clinical studies for the active ingredients used in Perfect Beauty Life® Sun, in combination with the clinical study conducted with the Lycolignol®-Complex contained in Perfect Beauty Life® Anti Aging, the conclusion can be drawn that Perfect Beauty Life® Sun helps to prepare the skin for exposure to sunlight, promoting a healthy skin from within and providing protection against antioxidants.

Author: Dr. Marc Schneider (Head of Business Development); marc.schneider@aenova-group.com

These documents are protected by copyright.
All rights, including those of translation, reprinting and reduplication of the documents or parts thereof, are reserved.  No part of the documents may be reproduced in any form whatsoever, including for teaching purposes, or processed, reduplicated or disseminated by electronic systems without the written approval of the author.  The author provides absolutely no guarantee for the up-to-dateness, correctness, completeness or quality of the information provided; any claims related to this are excluded, unless there is provable intent or gross negligence by the author.

References

  1. Argan oil: from nutrition to health; A. Adlouni; Phytothérapie (2010) 8: 89–97
  2. Therapeutic potential of argan oil: a review; Hanae El Monfaloutia,b, Dom Guillaumea, Clément Denheza and Zoubida Charroufb; Journal of Pharmacy and Pharmacology 2010, 62: 1669–1675
  3. Argan oil and other argan products: Use in dermocosmetology; Dominique Guillaume and Zoubida Charrouf; Eur. J. Lipid Sci. Technol. 2011, 113, 403–408
  4. A novel micronutrient supplement in skin aging: a randomized placebo-controlled doubleblind study; Alain Béguin; Skin Testing Department, Intercosmetica Neuchâtel SA, Neuchâtel, Switzerland
  5. Natural Astaxanthin: King of the Carotenoids; Bob Capelli with Dr. Gerald Cysewski; Copyright 2007 by Cyanotech Corporation; ISBN-13: 978-0-9792353-0-6
  6. Cosmetic benefits of astaxanthin on humans subjects; Kumi Tominaga, Nobuko Hongo, Mariko Karato and Eiji Yamashita; Biochimica Polonia; Vol. 59, No 1 /2012 43-47
  7. Anti-Inflammatory and Skin-Hydrating Properties of a Dietary Supplement and Topical Formulations Containing Oligomeric Proanthocyanidins; B. Hughes-Formella O. Wunderlich R. Williams; Skin Pharmacol Physiol 2007;20:43–49
  8. Therapeutic Pragmatism of Grape Fruit; Raaz K Maheshwari, Upma Singh, Nidhi Gauba Dhawan, Itishri Bhati, Bina Rani; Int. J. Chem. Pharm. Sci. 2013,Vol.1(3) 237 – 242
  9. EFSA Journal 2009; 7(9):1226
  10. EFSA Journal 2010;8(10):1816
  11. EFSA Journal 2010;8(10):1819
  12. EFSA Journal 2009; 7(9):1229
  13. EFSA Journal 2009; 7(9):1211
  14. EFSA Journal 2009; 7(9):1209

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