Perfect Beauty Life® Reduce Cellulite 2017-11-14T01:43:52+00:00

PBL_cellulite_head

Beauty from Inside Out

logo-product-of-swiss logo-GMP logo-efsa logo-aenova logo-conformity
 logo-ISO14001  logo-circle-label  logo-ISO14001_p3  logo-swisscap  logo-ISO14001_p2
Key Ingredients
Scientific Summary

External beauty treatments alone are no longer enough, because natural beauty comes from inside out. The reason for this is easy to explain. The deeper layers of the skin have a crucial influence on our appearance. Our skin can only look radiant when these layers are well nourished. This is why a good supply of essential nutrients from inside out plays a decisive role in beauty and in the appearance of the skin in particular.

The Perfect Beauty Life® Range are brand new Nutricosmetic products with unique and innovative formulations containing the specially designed Lycolignol® -Complex clinical study in Germany, supervised by dermatologists and nutritionists. It is a scientific break-through in the beauty from inside out market.

Specially designed Lycolignol®-Complex:
The Lycolignol® -Complex is a unique high-quality blend of three ingredients. It combines special grades of flaxseed extract, green tea extract and lycopene-rich tomato extract.

It has proven antioxidant properties and protects the skin against the negative effects of free radicals.

  • Lycolignol® -Complex in the same composition as Perfect Beauty Life® Anti Age, which is clinically tested and proven in Germany, supervised by dermatologists and nutritionists.
  • Unique and innovative compositions
  • Premium raw materials (partially EFSA approved health claims)
  • Special visual appearance due to pearl effect colours
  • Dosage form: soft gelatin capsule
  • Size: 9 minims
  • Form: oval
  • Recommended dose: 2 capsules daily with meals

Strengthen your Skin Structure

Supports the targeted action on orange peel skin dimpling to drain away and restructure the skin from inside out. Lycolignol® -Complex combined with conjugated linoleic acid, L-Carnitine and caffeine.

reduce_cellulite_pic2

Cellulite or orange peel skin is a major problem for around 80 percent of women. A weak skin structure is generally a hereditary factor and plays a significant role in the development of cellulite. The high-quality ingredients in Perfect Beauty Life® Cellular have a positive influence on the skin structure from inside out and support the metabolic process. Caffeine stimulates the 1 degradation of fats during lipolysis through inhibition of the phosphodiesterase activity.  Conjugated linoleic acid (CLA) can positively affect body composition by significantly reducing fat mass mostly around the legs. L-Carnitine boosts the metabolism and promotes the burning of fat. Perfect Beauty Life® Cellular helps to reduce cellulite and to make the skin smoother and firmer.

reduce_cellulite_graphic

1: Caffeine’s mechanisms of action and its cosmetic use: 2013; 26(1): 8-14. doi: 10.1159 / 000343174. Epub 2012 Oct 11
2: British Journal of Nutrition (2007), 97, 550-560, Gaullier et al 2007

Key Ingredients

Lycolignol®-Complex: Has proven antioxidant properties and protects the skin against the negative effects of free radicals, clinical study in Germany, supervised by dermatologists and nutritionists.
Conjugated linoleic acid (CLA): support lean body mass and protect against free radicals. CLA is a strong plant antioxidant, can reduces the body fat without reducing muscle mass, reduces subcutaneous fat and the excess weight is gone for good. Prevents fat redeposition (anti yoyo effect) and aids slimming by reducing body fat and preserving lean muscle.
Manganese: contributes to normal energy-yielding metabolism and normal formation of connective tissue to the protection of cells from oxidative stress.
Caffeine: used as an active compound in anti-cellulite products, prevents excessive accumulation of fat in cells for cosmetic purpose. Stimulates the degradation of fats during lipolysis through inhibition of the phosphodiesterase activity. Caffeine is a potent antioxidant properties and “fat burner”. Contributes to the mobilization of fat stores and stimulation of fat release, increase fat burning and oxidation of stored fats. Caffeine helps to protect cells against the UV radiation and slows down the process of photoaging of the skin. Stimulates the growth of hair, helps generate a negative energy balance and increase calorie burning.

Vitamin C: Contributes to normal collagen formation and the normal function of skin. It also contributes to the protection of cells from oxidative stress.
Vitamin E: Contributes to the protection of cells from oxidative stress.
Chromium: contributes to normal macronutrient metabolism and maintenance of normal blood glucose levels.
Copper: Contributes to normal hair and skin pigmentation. Contributes to maintenance of normal connective tissues. Contributes to the protection of cells from oxidative stress.
L-Carnitine: contributes to weight loss by increasing your energy burn and reduces oxidative stress. Helps the energy production in the cell (by transporting fatty acids in places where they are used and metabolized/contributes to the fat burning during exercise/contributes to increased fat oxidation/is important for the oxidation of fat/helps improve muscle recovery after exercise/helps maintain optimal repair of muscle tissue/transports long-chain fatty acids into the mitochondria/plays an important role in lipid metabolism/can support lipid metabolism converts fatty acids into energy/turns fat into energy/helps to increase fatty acid oxidation in healthy humans.

Composition Amount per capsule % of NRV*
Conjugated linoleic acid (CLA) 150 mg **
Lycolignol® -Complex 90 mg **
Vitamin C ♦ 60 mg 75
Vitamin E ♦ 6 mg 50
Chromium ♦ 40 mcg 100
Copper ♦ 0.5 mg 50
Manganese 1 mg 50
Caffeine 10 mg **
L-Carnitine 60 mg **

 

* NRVs: Nutrient Reference Values for the daily intake as defined in Regulation (EU) No. 1169/2011
** No NRVs defined
♦ Positive EFSA opinion avaiable (related to the ingredient not to the indication)

Stability study according to ICH guidelines

Stability tests have been performed on a long-term basis to determine an optimal shelf-life.

  • Climatic Zone II: 25 C / 60% RH, duration: 3 years
  • Climatic Zone III: 30 C / 65% RH, duration: 1 year
  • Climatic Zone IV: 40 C / 75% RH, duration: 6 months

Current stability results indicate a shelf life of 24 months

Special appearance

  • Dosage form: soft gelatin capsule
  • Size: 9 minims 750 mg per capsule
  • Form: oval
  • Colour: pink with shimmer
  • Recommended dose: two capsules daily
  • 1 softcap with main meals, twice a day for much better resorption to have higher bioavailability.
  • Optimum result will be seen in 90 days

The Science behind and mode of action of

Perfect Beauty Life® Cellular – Strengthen your skin structure
– Scientific Summary –

The term “cellulite” refers to the dimpled appearance of the skin that some people have on their hips, thighs, and buttocks. Cellulite is also called “orange-peel” or “cottage cheese” skin. This appearance is much more common in women than in men because of differences in the way fat, muscle, and connective tissue are distributed under men’s and women’s skin. Cellulite is a complex disorder involving the micro-circulatory and lymphatic systems, the extracellular matrix and the presence of excess subcutaneous fat that bulges into the dermis which is caused by fat deposits that push and distort the connective tissues beneath skin, leading to the characteristic changes in the appearance of the skin.

Perfect Beauty Cellular is a particular combination of ingredients such as conjugated linoleic acid (CLA), caffeine, L-Carnitine and the specially designed Lycolignol® – Complex. In addition, vitamin C and E, chromium, copper and manganese complement this formulation to support the skin with ingredients that can reduce cellulite.

Lycolignol® -Complex

The Lycolignol® -Complex is a unique, high-quality blend of three ingredients. It combines special grades of flaxseed extract, green-tea extract, and also lycopenerich tomato extract. This specially designed blend has been tested positive in a human clinical study. The antioxidant properties of the ingredients improve the condition and firmness of the skin, and are believed to catch free radicals.

Conjugated linoleic acid

In a human study, Birnbaum et al. 2001 compared the effects of a herbal anti-cellulite pill with increasing concentrations of CLA over 60 days. These treatments had a beneficial effect on thigh-circumference reduction in 75% of the women. It demonstrated improvements in thigh cellulite appearance and reductions in thigh circumference measurements on completion of the study. Improvements in microcirculatory patterns were also observed. Although no further studies with CLA have been conducted especially on cellulite, CLA has repeatedly been shown to reduce body fat mass in obese individuals with a corresponding increase in lean body mass (A. V. Rawlings; 2006; Lawrence Birnbaum, 2001).

The way in which CLA improves body composition is still under investigation, but several mechanisms have been proposed. CLA is known to influence many of the enzymes involved in fat metabolism, e.g. lipoprotein lipase, stearoyl-CoA desaturase, and fatty-acid binding protein. In addition, CLA has been shown not only to modify fat metabolism, but also adipocyte growth and differentiation, therefore modifying the exact site of fat storage. Such modification of many processes leading to an overall reduction in fat storage, and ultimately fat mass, is thought to be the result of CLA acting as an agonist to certain nuclear transcription factors that control all of these processes. At the same time, CLA increases the activity of an enzyme that increases the breakdown of fats. The storage of fat is therefore reduced, fat is burned at a higher rate, and less muscle tissue is broken down for energy during a catabolic state. This leads to a reduction in fat mass and an increase in lean muscle mass. A recent study found that daily consumption of CLA significantly reduces fat mass, mostly in the legs (Scientific Background Information on Clarinol™).

Caffeine

Extracts from coffee have a wide spectrum of action and are used in many kinds of cos-metics. Caffeine stimulates the metabolism, contributes to the removal of deposits of toxins from the organism, reduces puffy eyes, accelerates the drainage of the lymph system from fatty tissue, improves the microcirculation of the blood in the capillary vessels, exhibits anti-cellulite properties, activates lipolysis, and releases excess fat from adipocyte cells by reducing their size (A. Herman, A.P. Herman, 2013).

As for its cosmetic applications, caffeine is used as an active compound in anticellulite products because it prevents excessive accumulation of fat in cells. This alkaloid stimulates the degradation of fats during lipolysis through inhibition of phosphodiesterase activity. Caffeine also has potent antioxidant properties. Furthermore, caffeine contained in cosmetics increases the microcirculation of blood in the skin, and also stimulates the growth of hair through inhibition of 5-α -reductase activity. The study performed by Lupi et al. 2007 showed that an oral intake facilitated a reduction in cellulite and improved the microcirculatory blood flow in all women taking part in this clinical study (A. Herman, A.P. Herman, 2013).

L-Carnitine

Carnitine is found in almost all of your body’s cells. It plays a crucial role in helping the fat metabolism. L-carnitine transports long-chain fatty acids across the inner mitochondrial membranes in the mitochondria, where they are processed by betaoxidation to produce biological energy in the form of adenosine triphosphate or ATP. In this way, fat is used as an energy source. In addition, L-carnitine transports toxic compounds out of the mitochondria to prevent accumulation. The effectiveness of carnitine has been demonstrated in various human studies (R. Roure et al. 2011).

One of these studies demonstrates the efficacy of an active product combining Tetrahydroprotoberberines (THPB), caffeine, carnitine, forskolin and retinol to combat cellulite. It demonstrates the mechanism of action of the active ingredients. In this double-blind, randomized, placebo-controlled study demonstrated the clinical interest of this new combination of actives. After 12 weeks of twice-daily intake, the centimetric reductions were significant vs. the baseline in all the body areas studied (arm, abdomen, thighs, hips-buttocks and waist). Orange peel and stubborn cellulite grading were significantly reduced as well. lt was observed that the skin tonicity and stubbom cellulite were improved mostly on the buttocks compared with the other tested areas. This may be explained by a more severe state at baseline. On the contrary, changes observed in the orange peel aspect were consistent between the four areas during the whole study and between the different time points. After 12 weeks of treatment compared with placebo, the anticellulite product significantly improved skin condition in eight parameters of the thirteen evaluated (R. Roure et al. 2011).

Vitamin C

A cause-and-effect relationship has been established between the dietary intake of vitamin C and normal collagen formation. The European Food Safety Authority (EFSA) considers that the following wording reflects the scientific evidence: “Vitamin C contributes to normal collagen formation and the normal function of skin” (EFSA Journal 2009; 7(9):1226).

Vitamin C functions physiologically as a water-soluble antioxidant and plays a major role as a free-radical scavenger (Sadler et al., 1999; IoM, 2000). It is part of the antioxidant defence system, which is a complex network including endogenous and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects between the various components. The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of vitamin C and the protection of DNA, proteins and lipids from oxidative damage (EFSA Journal 2009; 7(9):1226).

Vitamin E

Vitamin E is also part of the antioxidant defence system, which is a complex network in-cluding both endogenous and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects among the various components. (Shils et al., 2006; IoM 2000). Reactive oxygen species (ROS) can damage molecules such as DNA, proteins and lipids if they are not intercepted by the antioxidant network, which includes free-radical scavengers such as antioxidant nutrients. The EFSA points out that a cause-and-effect relationship has been established between the dietary intake of vitamin E and protection of DNA, proteins and lipids from oxidative damage. The following wording reflects the scientific evidence: “Vitamin E contributes to the protection of cell constituents from oxidative damage” (EFSA Journal 2010;8(10):1816).

Chromium

Chromium depletion that responds to chromium supplementation has been reported in humans receiving long-term total parenteral nutrition (TPN) with TPN solutions low in or free of chromium. Jeejeebhoy et al. (1977) reported on a female receiving longterm parenteral nutrition for three and a half years, who exhibited impaired glucose tolerance and glucose utilisation, weight loss, neuropathy, elevated plasma fatty acids, depressed respiratory quotient and abnormalities in nitrogen metabolism. A patient receiving total parenteral nutrition low in chromium for five months after complete bowel resection developed severe glucose intolerance, weight loss and a metabolic encephalopathy-like confusional state (Freund et al., 1979). Hyperglycaemia is a common feature of chromium depletion in humans. It can be reversed by the administration of chromium (Jeejeebhoy et al., 1977; Freund et al., 1979; Brown et al., 1986; SCF, 1993; IoM, 2001; EVM, 2002). The EFSA considers that the following wording reflects the scientific evidence: “Chromium contributes to the maintenance of normal blood glucose levels” (EFSA Journal 2010:8(10):1732).

Copper

Symptoms of severe copper deficiency include lack of collagen maturation. Copper is a cofactor of an extracellular enzyme called lysyl oxidase, which is critical to the formation and functioning of connective tissue. The reaction of oxidative deamination of specific lysine residues in the extracellular matrix initiates the formation of cross-links that stabilize newly formed elastin and collagen (Linder and Hazegh-Azam, 1996).

The role of copper in the pigmentation of skin is related to the requirement of cuproenzyme tyrosinase (monophenol oxidase) for melanin synthesis. Mutational loss of this catalytic function for example leads to albinism (Arredondo and Nunez, 2005; Linder, 1991). The EFSA considers that the following wording reflects the scientific evidence: “Copper contributes to normal skin and hair pigmentation” (EFSA Journal 2009; 7(9):1211).

Manganese

Manganese is essential as a co-factor for the metalloenzymes superoxide dismutase (SOD), xanthine oxidase, arginase, galactosyltransferase and pyruvate carboxylase. Manganese also activates a number of other enzymes such as various decarboxylases, hydrolases, kinases and transferases, for example glycolsyltranferases, and glutamine synthetase. Manganese is not essential for the activity of most of these enzyme systems, which can also be activated by other metals, with the exception of glycosyltransferases (JHCI, 2003; Buchman, 2006). Manganese deficiency interferes with normal skeletal development in various animal species (Combs et al., 1942; Leach and Muenster, 1962; Tsai and Everson, 1967). Glycosyltranferases and xylosyltransferases are important for proteoglycan synthesis and thus the formation of connective tissue, including that in bone and cartilage, and these enzymes are sensitive to manganese intake and status in animals (JHCI, 2003; IoM, 2000; Buchman, 2006). The very few cases of manganese deficiency in humans have been induced in experimental conditions (Buchman, 2006). The EFSA considers that the following wording reflects the scientific evidence: “Manganese contributes to the normal formation of connective tissue” (EFSA Journal 2010:8(10):1808).

SOD catalyzes the dismutation of superoxide into oxygen and hydrogen peroxide, and as such it is an important antioxidant defence in nearly all cells exposed to oxygen. SOD2 (Mn-SOD) is the isoenzyme of SOD present in mitochondria. Its synthesis is regulated by manganese through a mechanism of gene activation, and reduced activity of the enzyme has been shown in manganese deficiency in mice. Mice lacking Mn-SOD die a few days after birth owing to massive oxidative stress. Tissue Mn-SOD activity in-creases after exposure to environmental factors inducing an increase in free radicals (JHCI, 2003; Buchman, 2006). The EFSA considers that the following wording reflects the scientific evidence: “Manganese contributes to the protection of cell constituents from oxidative damage” (EFSA Journal 2009; 7(9):121).

Conclusion

Based on the scientific data and the clinical studies for the active ingredients used in Perfect Beauty Cellular, in combination with the clinical study conducted with the Lycolignol® -Complex contained in Perfect Beauty Anti Age, the conclusion can be drawn that Perfect Beauty Cellular helps to reduce obvious signs of cellulite and makes the skin appear smoother and firmer.

Author: Dr. Marc Schneider (Director of Business Development Consumer Healthcare);
marc.schneider@aenova-group.com

These documents are protected by copyright.
All rights, including those of translation, reprinting and reduplication of the documents or parts thereof, are reserved. No part of the documents may be reproduced in any form whatsoever, including for teaching purposes, or processed, reduplicated or disseminated by electronic systems without the written approval of the author. The author provides absolutely no guarantee for the up-to-dateness, correctness, completeness or quality of the information provided; any claims related to this are excluded, unless there is provable intent or gross negligence by the author.

References

  1. Cellulite and its treatment; A. V. Rawlings; 2006 International Journal of Cosmetic Science, 28, 175–190
  2. Addition of Conjugated Linoleic Acid to a Herbal Anticellulite Pill; Lawrence Birnbaum, M.D.; Advances In Natural Therapy, Volume 18 No.5 September/October 2001
  3. Scientific Background Information on Clarinol™ CLA; Lipid Nutrition
  4. Caffeine’s mechanisms of action and its cosmetic use; A. Herman, A.P. Herman; Skin Pharmacol Physiol 2013;26:8–14
  5. Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, in in vitro, ex vivo and in vivo studies; R. Roure, T. Oddos, A. Rossi, F. Viall and C. Bertin; International Journal of Cosmetic Science, 2011, 33, 519-526
  6. EFSA Journal 2009; 7(9):1226
  7. EFSA Journal 2010;8(10):1816
  8. EFSA Journal 2010:8(10):1732
  9. EFSA Journal 2009; 7(9):1211
  10. EFSA Journal 2010:8(10):1808
  11. EFSA Journal 2009; 7(9):121

The Aenova Group is one of the world’s largest contract manufacturers and service providers for solid, semi-solid and liquid dosage forms for the pharmaceutical and healthcare industries.

Manufactured for Worldsalud Ltd by Swiss Caps AG. Switzerland
A member of Aenova Group