Perfect Beauty Life® Improve Moisture 2017-11-14T01:43:52+00:00

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Beauty from Inside Out

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Key Ingredients
Scientific Summary

External beauty treatments alone are no longer enough, because natural beauty comes from inside out. The reason for this is easy to explain. The deeper layers of the skin have a crucial influence on our appearance. Our skin can only look radiant when these layers are well nourished. This is why a good supply of essential nutrients from inside out plays a decisive role in beauty and in the appearance of the skin in particular.

The Perfect Beauty Life® Range are brand new Nutricosmetic products with unique and innovative formulations containing the specially designed Lycolignol® -Complex clinical study in Germany, supervised by dermatologists and nutritionists. It is a scientific break-through in the beauty from inside out market.

Specially designed Lycolignol®-Complex:
The Lycolignol® -Complex is a unique high-quality blend of three ingredients. It combines special grades of flaxseed extract, green tea extract and lycopene-rich tomato extract.

It has proven antioxidant properties and protects the skin against the negative effects of free radicals.

  • Lycolignol® -Complex in the same composition as Perfect Beauty Life® Anti Age, which is clinically tested and proven in Germany, supervised by dermatologists and nutritionists.
  • Unique and innovative compositions
  • Premium raw materials (partially EFSA approved health claims)
  • Special visual appearance due to pearl effect colours
  • Dosage form: soft gelatin capsule
  • Size: 9 minims
  • Form: oval
  • Recommended dose: 2 capsules daily with meals

Retain your moisture balance

A new generation for a balanced and firm skin to improve moisture from inside. Lycolignol® – Complex combined with advocado oil, hyaluronic acid and collagen.

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If the skin is deprived of moisture, it will dry out very quickly. As a result, it will look pale, greyish and taut. A lack of moisture can also cause wrinkles to form. Perfect Beauty Life® Moisture rectifies these problems with its unique ingredients, such as hyaluronic acid and collagen, which is present in natural form in human tissue and is able to retain large quantities of moisture. This helps to plump up existing wrinkles from inside out and gives the skin a fresher and younger appearance1, together with a natural radiance.

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Collagen: source by Dr Ananya Mandal, MD. Collagen is a protein made up of amino-acids, which are in turn built of carbon, oxygen and hydrogen. Collagen contains specific amino acids – Glycine, Proline, Hydroxyproline and Arginine. Collagen makes up approximately 30% of the proteins within the body. These are tough and strong structures found all over the body: in bones, tendons and ligaments. Collagen helps to give strength to various structures of the body and also protects structures like the skin by preventing absorption and spreading of pathogenic substances, environmental toxins, micro – organisms and cancerous cells. Collagen protein is the cement that holds everything together. Collagen is even the major component of the hair and nails. With age, collagen production slows and the cells structures weaken. The skin gets thinner and is easier to damage, hair gets lifeless, skin sags and wrinkles, tendons and ligaments become less elastic, joints get stiff etc.

1.Aesthetic Dermatology Vol.12: 109-102,2002: Clinical effects of dietary hyaluronic acid on dry, rough skin.

Key Ingredients

Lycolignol®-Complex: Has proven antioxidant properties and protects the skin against the negative effects of free radicals, clinical study in Germany, supervised by dermatologists and nutritionists.
Avocado oil: consists of 71% monounsaturated fatty acids (MUFA), 13% polyunsaturated fatty acids (PUFA), and 16% saturated fatty acids (SFA), which helps to promote healthy blood lipid profiles and enhance the bioavailability of fat soluble vitamins and phytochemicals. Helps support cardiovascular health and weight management and healthy aging. Avocados have the highest fruit lipophilic antioxidant capacity, which may be one factor in helping to reduce serum lipid peroxidation and promoting vascular health, contains fruit phenolics which play a role in enhancing cardiovascular health. Avocado’s highly bioavailable lutein and zeaxanthin may help to protect the skin from damage from both UV and visible radiation.
Collagen: main structure protein of the skin, specific collagen peptides show beneficial effects on skin physiology and positive effects on skin elasticity, skin moisture and transepidermal water loss. It contains the natural endogenous humectant hyaluronic acid, which is found in the epidermis and is important for maintaining normal stratum corneum structure and epidermal barrier function. It maintains the normal hydration of the skin

Vitamin C: Contributes to normal collagen formation and the normal function of skin. It also contributes to the protection of cells from oxidative stress.
Vitamin E: Contributes to the protection of cells from oxidative stress.
Zinc: Contributes to the maintenance of normal hair, nails and skin. Contributes to the protection of cells from oxidative stress. Has a role in the process of cell division.
Copper: Contributes to normal hair and skin pigmentation. Contributes to maintenance of normal connective tissues. Contributes to the protection of cells from oxidative stress.
Hyaluronic acid: helps to keep good health of skin helps to keep young look of skin and maintain good skin hydration. Possesses a number of protective physiochemical functions. This is important for modulating tissue hydration and have significantly influences hydration and the physical properties of the skin.

Composition Amount per capsule % of NRV*
Avocado oil 180mg **
Lycolignol® -Complex 90 mg **
Vitamin C ♦ 20mg 25
Vitamin E ♦ 6 mg 50
Zinc ♦ 0.75 mg 7.5
Copper ♦ 0.5 mg 50
Hyaluronic acid 5 mg **
Collagen
of which hyaluronic acid
150 mg
15 mg
**

 

* NRVs: Nutrient Reference Values for the daily intake as defined in Regulation (EU) No. 1169/2011
** No NRVs defined
♦ Positive EFSA opinion avaiable (related to the ingredient not to the indication)

Stability study according to ICH guidelines

Stability tests have been performed on a long-term basis to determine an optimal shelf-life.

  • Climatic Zone II: 25 C / 60% RH, duration: 3 years
  • Climatic Zone III: 30 C / 65% RH, duration: 1 year
  • Climatic Zone IV: 40 C / 75% RH, duration: 6 months

Current stability results indicate a shelf life of 24 months

Special appearance

  • Dosage form: soft gelatin capsule
  • Size: 9 minims 750 mg per capsule
  • Form: oval
  • Colour: dark green with shimmer
  • Recommended dose: two capsules daily
  • 1 softcap with main meals, twice a day for much better resorption to have higher bioavailability.
  • Optimum result will be seen in 90 days

The Science behind and mode of action of

Perfect Beauty Life® Moisture – Retain your moisture balance
– Scientific Summary –

There’s nothing worse than dry, itchy skin! Adequate skin hydration is critical in maintaining healthy skin, and moisturizers are an important component of basic skin care. They protect the skin by stimulating its natural barrier function, and thereby keep up with its constant demand for moisture. Water is absolutely essential for the normal functioning of the skin, and especially in its outer layer, the stratum corneum (SC). Under normal conditions, the SC has a water content of 10% to 30%. This water gives the skin its soft, smooth, and flexible texture. The ability of the skin to hold water is mainly related to the SC, which plays the role of a barrier, minimizing water loss. By restoring the skin barrier, moisturizers protect the skin from daily damage arising from the environment, and consequently help to prevent skin aging.

The influence of nutritional factors on the skin has received increasing attention. Cosgrove et al. 2007 evaluated the association between nutrient intakes and skin-aging appearance (wrinkled appearance, senile dryness and skin atrophy), and concluded that higher intakes of vitamin C and other nutrients result in better skin appearance.

Perfect Beauty Life® Moisture is an effective combination of special ingredients such as avocado oil, hyaluronic acid, collagen, and the specially designed Lycolignol®-Complex. In addition, vitamin C, vitamin E, zinc and copper complete the formulation for a moisturized and smooth skin.

Perfect Beauty Life® Moisture works by using the combination of ingredients and the Lycolignol®-Complex. These scientifically proven ingredients work together with the vitamins and minerals to defend vital components of the skin against both direct and indirect damage, and also slow down the signs for dry and itchy skin.

Lycolignol®-Complex

The Lycolignol®-Complex is a unique, high-quality blend of three ingredients. It combines special grades of flaxseed extract, green-tea extract, and also lycopene rich tomato extract. This specially designed blend has been positive tested in a human clinical study. It has shown significant improvements in skin-dryness conditions, resulting from the antioxidant properties of the Lycolignol®-Complex that lead to a balanced skin texture in terms of moisture and softness.

Avocado Oil

Avocado oil is well known as an active ingredient in nutri-cosmetic products, and helps relieve dry and itchy skin conditions. Clinical studies on topical application of avocado oil show that it is deeply absorbed by the skin, thus making it an ideal moisturizer and skin-care agent.

A cross-sectional study examined the relationship between skin anti-aging and diet choices in 716 women. After controlling for covariates including age, smoking status, BMI, and lifetime sun exposure, the results showed that higher intakes of total dietary fat, in particularly unsaturated fatty acids, were significantly associated with more skin elasticity (Nagata et al., 2010).

Several pre-clinical studies suggest that avocado ingredients promote skin health by enhancing wound-healing activity and reducing UV damage (Nayak et al., 2008; Rosenblat et al., 2011).1

Hyaluronic Acid

Hyaluronic Acid (HA) – a high molecular weight glycosaminoglycan with markedly hydrophilic properties – is well known as one of the major substances in the dermis, and there is a tendency for the amount of this substance to decrease with age. However, it has been reported that hyaluronic acid is also naturally present in the epidermis, and may play a role in epidermal barrier functioning and SC hydration3.  In the dermis, HA contributes significantly to the hydration of the skin.

Due to this fact, HA has already been applied in many cosmetic products that have been commercialized with the objective of preserving the skin’s moisture. It is generally well known that supplementation with HA is a helpful approach in maintaining the health of the skin. A placebo-controlled, double-blind study of dietary hyaluronic acid in tablet form was performed over a six-week period on 22 individuals who tended to have routinely dry, rough skin. The results clarified the following points: 1. HA improves skin problems such as dryness, itchiness and redness, as well as damage due to cosmetics, erosion and exfoliation; 2. Measurement of skin moisture content showed that HA increased moisture content in the skin; 3. lt was shown by microscopic, 3-dimensional skin-surface analysis that HA improved skin smoothness.2

Collagen and Vitamin C

From a clinical point of view, Sumida et al. 2004 evaluated the effect of daily ingestion of collagen on the skin hydration of healthy women compared to a placebo group. A gradual improvement in water-absorption capacity was observed over 60 days in those volunteers who ingested collagen, in comparison with the placebo group. It is important to emphasize that the supplement administered to both the groups in this study also contained vitamin C. Therefore, it could be suggested that the collagen effect happened along with vitamin C.4

Vitamin C is a coenzyme for three different dioxygenase enzymes that stabilize the triplehelix structure of collagen. Normal collagen formation is required for the structuring of all connecting tissue in the body, including the skin. Vitamin C deficiency is exemplified by clinical signs attributable to impaired collagen synthesis (Sadler et al., 1999; Shils et al., 2006; IoM, 2000).

A cause-and-effect relationship has been established between the dietary intake of vitamin C and normal collagen formation. The European Food Safety Authority (EFSA) considers that the following wording reflects the scientific evidence: “Vitamin C contributes to normal collagen formation and the normal function of skin.” 5

Vitamin C functions physiologically as a water-soluble antioxidant and plays a major role as a free-radical scavenger (Sadler et al., 1999; IoM, 2000). It is part of the antioxidant defense system, which is a complex network including endogenous antioxidants and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects between the various components. The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of vitamin C and the protection of DNA, proteins and lipids from oxidative damage.5

Vitamin E

Vitamin E is also part of the antioxidant defense system, which is a complex network including both endogenous and dietary antioxidants, antioxidant enzymes and repair mechanismus, with mutual interactions and synergetic effects among the various components. (Shils et al., 2006; IoM 2000). Reactive oxygen species (ROS) can damage molecules such as DNA, proteins and lipids if they are not intercepted by the antioxidant network, which includes free-radical scavengers such as antioxidant nutrients. The EFSA points out that a cause-and-effect relationship has been established between the dietary intake of vitamin E and protection of DNA, proteins and lipids from oxidative damage. The following wording reflects the scientific evidence: “Vitamin E contributes to the protection of cell constituents from oxidative damage”.6

Zinc

Zinc plays an essential structural, regulatory or catalytic role in many enzymes, and maintains the configuration of a number of non-enzymatic proteins, facilitates hormone and receptor binding at membrane and nuclear levels, and contributes to the integrity of bio-membranes. Consequently, zinc participates in gene expression and in the mechanism and control of major metabolic pathways involving proteins, carbohydrates, nucleic acids and lipids (SCF, 1993; DoH, 1991). Human zinc-deficiency symptoms include skin lesions such as changes in the regeneration of the skin (SCF, 2003; EVM, 2002, Cousins, 2006). The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of zinc and the maintenance of normal skin. The following wording reflects the scientific evidence: “Zinc contributes to the maintenance of normal skin” 7, and “Zinc contributes to the protection of cell constituents from oxidative damage”.8

Copper

Symptoms of severe copper deficiency include lack of collagen maturation. Copper is a cofactor of an extracellular enzyme called lysyl oxidase (LO), which is critical to the formation and functioning of connective tissue . The reaction of oxidative deamination of specific lysine residues in the extracellular matrix initiates the formation of cross-links that stabilize newly formed elastin and collagen (Linder and Hazegh-Azam, 1996).

The role of copper in the pigmentation of skin is related to the requirement of cuproenzyme tyrosinase (monophenol oxidase) for melanin synthesis. Mutational loss of this catalytic function leads to albinism (Arredondo and Nunez, 2005; Linder, 1991). The EFSA considers that the following wording reflects the scientific evidence: “Copper contributes to normal skin and hair pigmentation”.9

Conclusion

Based on the scientific data and the clinical studies for the active ingredients used in Perfect Beauty Life® Moisture, in combination with the clinical study conducted with the Lycolignol®-Complex contained in Perfect Beauty Life® Anti Aging, the conclusion could be drawn that Perfect Beauty Life® Moisture enriches moisture in the skin and helps to eradicate existing wrinkles from within. It gives the skin a fresher and younger appearance, together with a natural radiance.

Author: Dr. Marc Schneider (Head of Business Development); marc.schneider@aenova-group.com

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All rights, including those of translation, reprinting and reduplication of the documents or parts thereof, are reserved.  No part of the documents may be reproduced in any form whatsoever, including for teaching purposes, or processed, reduplicated or disseminated by electronic systems without the written approval of the author.  The author provides absolutely no guarantee for the up-to-dateness, correctness, completeness or quality of the information provided; any claims related to this are excluded, unless there is provable intent or gross negligence by the author.

References

  1. Hass Avocado Composition and Potential Health Effects; Mark L. Dreher and Adrienne J. Davenport; Food Science and Nutrition, 53:738–750 (2013)
  2. Clinical effects of dietary hyaluronic acid on dry skin; Osami Kajamoto, Wataru Odanaka, Wakako Sakamoto, Kazuya Yoshida, Takeo Takahashi; Journal of New Remedies & Clinics Vol. 50 No. 5: 90(548) 102(560), 2001
  3. Skin hydration: a review on its molecular mechanisms; Sylvie Verdier-Sévrain, MD & Frédéric Bonté, PhD; Journal of Cosmetic Dermatology, 6, 75–82
  4. A new view concerning the effects of collagen hydrolysate intake on skin properties; Vivian Zague; Arch Dermatol Res (2008) 300:479–483
  5. EFSA Journal 2009; 7(9):1226
  6. EFSA Journal 2010;8(10):1816
  7. EFSA Journal 2010;8(10):1819
  8. EFSA Journal 2009; 7(9):1229
  9. EFSA Journal 2009; 7(9):1211

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