The Science behind and mode of action of
Perfect Beauty Life® Moisture – Retain your moisture balance
– Scientific Summary –
There’s nothing worse than dry, itchy skin! Adequate skin hydration is critical in maintaining healthy skin, and moisturizers are an important component of basic skin care. They protect the skin by stimulating its natural barrier function, and thereby keep up with its constant demand for moisture. Water is absolutely essential for the normal functioning of the skin, and especially in its outer layer, the stratum corneum (SC). Under normal conditions, the SC has a water content of 10% to 30%. This water gives the skin its soft, smooth, and flexible texture. The ability of the skin to hold water is mainly related to the SC, which plays the role of a barrier, minimizing water loss. By restoring the skin barrier, moisturizers protect the skin from daily damage arising from the environment, and consequently help to prevent skin aging.
The influence of nutritional factors on the skin has received increasing attention. Cosgrove et al. 2007 evaluated the association between nutrient intakes and skin-aging appearance (wrinkled appearance, senile dryness and skin atrophy), and concluded that higher intakes of vitamin C and other nutrients result in better skin appearance.
Perfect Beauty Life® Moisture is an effective combination of special ingredients such as avocado oil, hyaluronic acid, collagen, and the specially designed Lycolignol®-Complex. In addition, vitamin C, vitamin E, zinc and copper complete the formulation for a moisturized and smooth skin.
Perfect Beauty Life® Moisture works by using the combination of ingredients and the Lycolignol®-Complex. These scientifically proven ingredients work together with the vitamins and minerals to defend vital components of the skin against both direct and indirect damage, and also slow down the signs for dry and itchy skin.
The Lycolignol®-Complex is a unique, high-quality blend of three ingredients. It combines special grades of flaxseed extract, green-tea extract, and also lycopene rich tomato extract. This specially designed blend has been positive tested in a human clinical study. It has shown significant improvements in skin-dryness conditions, resulting from the antioxidant properties of the Lycolignol®-Complex that lead to a balanced skin texture in terms of moisture and softness.
Avocado oil is well known as an active ingredient in nutri-cosmetic products, and helps relieve dry and itchy skin conditions. Clinical studies on topical application of avocado oil show that it is deeply absorbed by the skin, thus making it an ideal moisturizer and skin-care agent.
A cross-sectional study examined the relationship between skin anti-aging and diet choices in 716 women. After controlling for covariates including age, smoking status, BMI, and lifetime sun exposure, the results showed that higher intakes of total dietary fat, in particularly unsaturated fatty acids, were significantly associated with more skin elasticity (Nagata et al., 2010).
Several pre-clinical studies suggest that avocado ingredients promote skin health by enhancing wound-healing activity and reducing UV damage (Nayak et al., 2008; Rosenblat et al., 2011).1
Hyaluronic Acid (HA) – a high molecular weight glycosaminoglycan with markedly hydrophilic properties – is well known as one of the major substances in the dermis, and there is a tendency for the amount of this substance to decrease with age. However, it has been reported that hyaluronic acid is also naturally present in the epidermis, and may play a role in epidermal barrier functioning and SC hydration3. In the dermis, HA contributes significantly to the hydration of the skin.
Due to this fact, HA has already been applied in many cosmetic products that have been commercialized with the objective of preserving the skin’s moisture. It is generally well known that supplementation with HA is a helpful approach in maintaining the health of the skin. A placebo-controlled, double-blind study of dietary hyaluronic acid in tablet form was performed over a six-week period on 22 individuals who tended to have routinely dry, rough skin. The results clarified the following points: 1. HA improves skin problems such as dryness, itchiness and redness, as well as damage due to cosmetics, erosion and exfoliation; 2. Measurement of skin moisture content showed that HA increased moisture content in the skin; 3. lt was shown by microscopic, 3-dimensional skin-surface analysis that HA improved skin smoothness.2
Collagen and Vitamin C
From a clinical point of view, Sumida et al. 2004 evaluated the effect of daily ingestion of collagen on the skin hydration of healthy women compared to a placebo group. A gradual improvement in water-absorption capacity was observed over 60 days in those volunteers who ingested collagen, in comparison with the placebo group. It is important to emphasize that the supplement administered to both the groups in this study also contained vitamin C. Therefore, it could be suggested that the collagen effect happened along with vitamin C.4
Vitamin C is a coenzyme for three different dioxygenase enzymes that stabilize the triplehelix structure of collagen. Normal collagen formation is required for the structuring of all connecting tissue in the body, including the skin. Vitamin C deficiency is exemplified by clinical signs attributable to impaired collagen synthesis (Sadler et al., 1999; Shils et al., 2006; IoM, 2000).
A cause-and-effect relationship has been established between the dietary intake of vitamin C and normal collagen formation. The European Food Safety Authority (EFSA) considers that the following wording reflects the scientific evidence: “Vitamin C contributes to normal collagen formation and the normal function of skin.” 5
Vitamin C functions physiologically as a water-soluble antioxidant and plays a major role as a free-radical scavenger (Sadler et al., 1999; IoM, 2000). It is part of the antioxidant defense system, which is a complex network including endogenous antioxidants and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects between the various components. The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of vitamin C and the protection of DNA, proteins and lipids from oxidative damage.5
Vitamin E is also part of the antioxidant defense system, which is a complex network including both endogenous and dietary antioxidants, antioxidant enzymes and repair mechanismus, with mutual interactions and synergetic effects among the various components. (Shils et al., 2006; IoM 2000). Reactive oxygen species (ROS) can damage molecules such as DNA, proteins and lipids if they are not intercepted by the antioxidant network, which includes free-radical scavengers such as antioxidant nutrients. The EFSA points out that a cause-and-effect relationship has been established between the dietary intake of vitamin E and protection of DNA, proteins and lipids from oxidative damage. The following wording reflects the scientific evidence: “Vitamin E contributes to the protection of cell constituents from oxidative damage”.6
Zinc plays an essential structural, regulatory or catalytic role in many enzymes, and maintains the configuration of a number of non-enzymatic proteins, facilitates hormone and receptor binding at membrane and nuclear levels, and contributes to the integrity of bio-membranes. Consequently, zinc participates in gene expression and in the mechanism and control of major metabolic pathways involving proteins, carbohydrates, nucleic acids and lipids (SCF, 1993; DoH, 1991). Human zinc-deficiency symptoms include skin lesions such as changes in the regeneration of the skin (SCF, 2003; EVM, 2002, Cousins, 2006). The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of zinc and the maintenance of normal skin. The following wording reflects the scientific evidence: “Zinc contributes to the maintenance of normal skin” 7, and “Zinc contributes to the protection of cell constituents from oxidative damage”.8
Symptoms of severe copper deficiency include lack of collagen maturation. Copper is a cofactor of an extracellular enzyme called lysyl oxidase (LO), which is critical to the formation and functioning of connective tissue . The reaction of oxidative deamination of specific lysine residues in the extracellular matrix initiates the formation of cross-links that stabilize newly formed elastin and collagen (Linder and Hazegh-Azam, 1996).
The role of copper in the pigmentation of skin is related to the requirement of cuproenzyme tyrosinase (monophenol oxidase) for melanin synthesis. Mutational loss of this catalytic function leads to albinism (Arredondo and Nunez, 2005; Linder, 1991). The EFSA considers that the following wording reflects the scientific evidence: “Copper contributes to normal skin and hair pigmentation”.9
Based on the scientific data and the clinical studies for the active ingredients used in Perfect Beauty Life® Moisture, in combination with the clinical study conducted with the Lycolignol®-Complex contained in Perfect Beauty Life® Anti Aging, the conclusion could be drawn that Perfect Beauty Life® Moisture enriches moisture in the skin and helps to eradicate existing wrinkles from within. It gives the skin a fresher and younger appearance, together with a natural radiance.
Author: Dr. Marc Schneider (Head of Business Development); firstname.lastname@example.org
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- Hass Avocado Composition and Potential Health Effects; Mark L. Dreher and Adrienne J. Davenport; Food Science and Nutrition, 53:738–750 (2013)
- Clinical effects of dietary hyaluronic acid on dry skin; Osami Kajamoto, Wataru Odanaka, Wakako Sakamoto, Kazuya Yoshida, Takeo Takahashi; Journal of New Remedies & Clinics Vol. 50 No. 5: 90(548) 102(560), 2001
- Skin hydration: a review on its molecular mechanisms; Sylvie Verdier-Sévrain, MD & Frédéric Bonté, PhD; Journal of Cosmetic Dermatology, 6, 75–82
- A new view concerning the effects of collagen hydrolysate intake on skin properties; Vivian Zague; Arch Dermatol Res (2008) 300:479–483
- EFSA Journal 2009; 7(9):1226
- EFSA Journal 2010;8(10):1816
- EFSA Journal 2010;8(10):1819
- EFSA Journal 2009; 7(9):1229
- EFSA Journal 2009; 7(9):1211
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