Perfect Beauty Life® Anti Aging 2017-11-14T01:43:52+00:00

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Beauty from Inside Out

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Key Ingredients
Scientific Summary
Product Dossier

External beauty treatments alone are no longer enough, because natural beauty comes from inside out. The reason for this is easy to explain. The deeper layers of the skin have a crucial influence on our appearance. Our skin can only look radiant when these layers are well nourished. This is why a good supply of essential nutrients from inside out plays a decisive role in beauty and in the appearance of the skin in particular.

The Perfect Beauty Life® Range are brand new Nutricosmetic products with unique and innovative formulations containing the specially designed Lycolignol® -Complex clinical study in Germany, supervised by dermatologists and nutritionists. It is a scientific break-through in the beauty-from-inside out market. Perfect Beauty Life® Anti Aging is characterized by a unique and innovative formulation (patent pending) containing the specially designed Lycolignol® -Complex. The efficacy of the soft capsules has been proven in a placebo-controlled, clinical study in Germany, supervised by dermatologists and nutritionists.

Perfect Beauty Life® Anti Aging improves significantly the skin dryness and roughness as well as the freshness of the facial appearance. Substantial improvement was observed in skin firmness and elasticity and also in the regularity of the skin tone.

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Unique selling propositions at a glance:

  • Special appearance of the capsule
  • Unique composition of raw materials
  • Ingredients with EFSA-approved health claims for skin and hair
  • Stability study according to ICH guidelines
  • Clinically proven efficacy in skin health improvement

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Only after 43 days of intake, substantial improvements in skin firmness and elasticity were observed. These two parameters are critical in measuring the anti-aging effects of the skin.

Clinically proven efficacy for skin health improvement
The efficacy of Perfect Beauty Life Anti Aging has been tested in a double-blind placebo-controlled clinical study in Germany, conducted over 3 months (two capsules per day).

Skin hydration (Corneometer), skin elasticity (Cutometer), skin sebum (Sebumeter®) and structure of collagen network and stratum corneum thickness (Confocal Microscopy Images) were assessed before intake of Perfect Beauty Life® Anti Aging and after 6 weeks and 12 weeks of intake. Visual evaluation of skin dryness, roughness, redness, wrinkles, comedones and dandruff were assessed by trained technicians. On completion of the study, these before-and-after images were evaluated by a trained panel, focused on skin structure, regular skin tone and fresh appearance.

71 volunteers aged between 18 and 45 years were enrolled in the study of whom 60 completed the study in accordance with the protocol or with minor deviations.

Perfect Beauty Life® Anti Aging makes my skin soft and more elastic, and I have a fresher skin complexion.
Volunteer, 43 years old
My hair is usually very dry. After taking Perfect Beauty Life® Anti Aging I have the impression that my hair looks healthier and has more moisture
Volunteer, 41 years old

Specially designed Lycolignol® -Complex
Perfect Beauty Life® Anti Aging contains the specially designed Lycolignol® -Complex, which is a highquality blend of three ingredients. It combines flax lignans, green tea polyphenols and lycopene derived from tomatoes.

The Lycolignol® -Complex has proven antioxidant properties and protects the skin against the negative effects of free radicals. It also makes the hair healthier and more beautiful.

Lycolignol® -Complex combined with a mix of nutrients containing evening primrose oil and selenium

  • Lycopene, in particular, promotes a healthy and beautiful skin.
  • Green tea polyphenols protect the skin against harmful UV radiation and help to improve overall skin quality. The polyphenols also show significant anti-inflammatory, anti-oxidant and anti-DNA damaging effects.
  • Lignans are phytoestrogens as well as powerful antioxidants. Flax is the richest natural source of lignans, which are beneficial in treatment of acne. Lignans promote a reduction in the oiliness of skin (sebum excretion) and have a positive effect on the complexion.

Other selected ingredients are evening primrose oil, vitamin C, vitamin E, zinc, copper and selenium.

Key Ingredients

Lycolignol® -Complex: has proven antioxidant properties and protects the skin against the negative effects of free radicals. It also makes the hair healthier and more beautiful.
Evening primrose oil: Polyunsaturated omega-6 fatty acids (gamma-linolenic acid) are essential components of cell membranes and can help to reduce inflammation. Gamma linolenic acid is an essential fatty acid for healthy skin and improves moisture, elasticity, firmness, fatigue resistance and skin roughness. Evening primrose oil also helps to nourish the scalp and has a hormone balancing effect.
Vitamin C: Contributes to normal collagen formation and the normal function of skin. It also contributes to the protection of cells from oxidative stress.

Vitamin C: Contributes to the protection of cells from oxidative stress.
Zinc: Contributes to the maintenance of normal hair, nails and skin. Contributes to the protection of cells from oxidative stress. Has a role in the process of cell division.
Copper: Contributes to normal hair and skin pigmentation. Contributes to maintenance of normal connective tissues. Contributes to the protection of cells from oxidative stress.
Selenium: Contributes to the maintenance of normal hair and nails. Contributes to the protection of cells from oxidative stress.

Composition Amount per capsule % of NRV*
Lycolignol -Complex contains
lycopene ♦ , polyphenols ♦ and lignans ♦
180 mg **
Evening primrose oil ♦
of which GLA (Gamma-linolenic acid)
165 mg
14 mg
**
Vitamin E • 6 mg α -TE 50
Vitamin C • 40 mg 50
Copper • 500 μg 50
Zinc • 5 mg 50
Selenium • 27.5 μg 50

* NRVs: Nutrient Reference Values for the daily intake as defined in Regulation (EU) No. 1169/2011
** No NRVs defined
♦ References from several scientific studies are available
• EFSA health claim available (related to the ingredient not to the indication)

Stability study according to ICH guidelines

Stability tests have been performed on a long-term basis to determine an optimal shelf-life.

  • Climatic Zone II: 25 C / 60% RH, duration: 3 years
  • Climatic Zone III: 30 C / 65% RH, duration: 1 year
  • Climatic Zone IV: 40 C / 75% RH, duration: 6 months

Current stability results indicate a shelf life of 24 months

Special appearance

  • Dosage form: soft gelatin capsule
  • Size: 9 minims 750 mg per capsule
  • Form: oval
  • Colour: pink with shimmer
  • Recommended dose: two capsules daily
  • 1 softcap with main meals, twice a day for much better resorption to have higher bioavailability.
  • Optimum result will be seen in 90 days

The Science behind and mode of action of

Perfect Beauty Life® Anti Aging  – Improve the signs of aged skin
– Scientific Summary –

Good nutrition plays an important role in maintaining healthy and attractive skin. Our skin is the largest organ of our body, and like any other organ it gets its nutrients through blood circulation and thus from our nutrition. For example, it plays an important role in delivering photo-protective effects to the skin.

The ageing of the skin is a continuous and visible process. Fortunately, certain ingredients in our food can slow down this ageing process to some extent. One of these is lycopene, a powerful antioxidant that gives tomatoes their natural red colour. Antioxidants are important weapons in the fight against free-radical damage, and are helpful in preventing premature skin ageing.

Perfect Beauty Life® Anti Aging is a carefully selected combination of ingredients such as evening primrose oil and the specially designed Lycolignol®-Complex. Vitamins C and E, zinc, copper and selenium complete the formulation to address the signs of ageing skin.

Clinical Study of the Perfect Beauty Life® Anti Aging

 The purpose of this explorative study was to assess the efficacy of a food supplement compared to a placebo over a period of three months. Skin hydration, elasticity and sebum, as well as the structure of the collagen network and stratum corneum (SC) thickness were assessed before intake of the test product and after 6 and 12 weeks. Visual evaluation of skin dryness, roughness, redness, wrinkles, comedones and dandruff was assessed by a trained technician and facial images were taken. At the end of the study, the images were evaluated in terms of skin tone and facial appearance by lay raters. 8

71 eligible male and female subjects were enrolled, of which 60 finished the study without major protocol deviations, with a mean age of 33.0 ± 8.3 years. 8

At day 1 (Baseline) a visual evaluation was performed by a trained technician and measurement of skin hydration, elasticity and sebum was performed. Assessment of collagen network and SC thickness was performed on 40 subjects (all with visible wrinkles). Standardized images were taken and the subjects received the test product or placebo and a diary. The subjects took two capsules daily for the next three months. All assessments were repeated after 6 weeks (day 43) as well as after 12 weeks (day 85). 8

Visual evaluation was performed by a trained technician on skin dryness, skin redness, skin roughness and dandruff. For subjects with a blemish skin-lesion, a count of comedones (black and white heads) in a defined area (cheeks, forehead etc.) was performed. For subjects with visible wrinkles, an evaluation of wrinkles around the eye was performed.8

Compared to the placebo, the food supplement improved skin dryness and skin roughness significantly in group 2 of the older women. Skin firmness was also improved in this group, but just missed the significance. Regularity of skin tone by tendency was improved in the complete test group after day 43, and in group 2 of the older women by day 43. In group 1 with the younger women, assessment of photographs revealed a significant improvement of freshness in their facial appearance by day 43. By tendency this effect was also observed in the complete test group by day 43. 8

In this exploratory study, the food supplement was well tolerated. Furthermore, it was effective in improving several of the assessed skin conditions.8

Lycolignol®-Complex

The Lycolignol®-Complex is a unique high-quality blend of three ingredients. It combines special grades of flaxseed extract, green tea extract and also lycopene-rich tomato extract. It has been proven to have antioxidant properties in a human study, and protects the skin against the negative effects of free radicals.

Evening Primrose Oil

Evening Primrose Oil (EPO) contains a high amount of the omega-6 fatty acid gamma linoleic acid (GLA) which is largely responsible for the remarkable healing properties of the plant. In fact, EPO contains one of the highest concentrations known of this important substance, and only a few other plants contain it in any quantity. This makes Evening Primrose an important medicinal herb, and as studies continue the list of benefits will very likely become much longer. The gamma-linoleic acid and other nutrients in this oil are essential for cell structure and improve the elasticity of the skin.

A randomized, double-blind, placebo-controlled study in healthy adults tested the effects of EPO on skin moisture, transepidermal water loss (TEWL), redness, firmness, elasticity, fatigue resistance and roughness. All the measured variables were significantly different in the EPO group compared with the placebo. Skin moisture, TEWL, elasticity, firmness, fatigue resistance and roughness had significantly improved. The present study indicates that the regular intake of evening primrose oil with a high GLA content strengthens the physiological skin barrier function, improves biomechanical properties and smoothes the surface profile of skin. 1

Vitamin C

A cause-and-effect relationship has been established between the dietary intake of vitamin C and normal collagen formation. The European Food Safety Authority (EFSA) considers that the following wording reflects the scientific evidence: “Vitamin C contributes to normal collagen formation and the normal function of skin.” 2

Vitamin C functions physiologically as a water-soluble antioxidant, and plays a major role as a free-radical scavenger (Sadler et al., 1999; IoM, 2000). It is part of the antioxidant defense system, which is a complex network including endogenous and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects between the various components. The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of vitamin C and the protection of DNA, proteins and lipids from oxidative damage. 2

Vitamin E

Vitamin E is also part of the antioxidant defense system, which is a complex network including both endogenous and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects among the various components. (Shils et al., 2006; IoM 2000). Reactive oxygen species (ROS) can damage molecules such as DNA, proteins and lipids if they are not intercepted by the antioxidant network, which includes free-radical scavengers such as antioxidant nutrients. The EFSA points out that a cause-and-effect relationship has been established between the dietary intake of vitamin E and protection of DNA, proteins and lipids from oxidative damage. The following wording reflects the scientific evidence: “Vitamin E contributes to the protection of cell constituents from oxidative damage”.3

Zinc

Zinc plays an essential structural, regulatory or catalytic role in many enzymes. It also maintains the configuration of a number of non-enzymatic proteins, facilitates hormone and receptor binding at membrane and nuclear levels, and contributes to the integrity of bio-membranes. Consequently, zinc participates in gene expression and in the mechanism and control of major metabolic pathways involving proteins, carbohydrates, nucleic acids and lipids (SCF, 1993; DoH, 1991). Human zinc-deficiency symptoms include skin lesions such as changes in the regeneration of the skin (SCF, 2003; EVM, 2002, Cousins, 2006). The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of zinc and the maintenance of normal skin. The following wording reflects the scientific evidence: “Zinc contributes to the maintenance of normal skin” 4, and “Zinc contributes to the protection of cell constituents from oxidative damage”.5

Copper

Symptoms of severe copper deficiency include lack of collagen maturation. Copper is a cofactor of an extracellular enzyme called lysyl oxidase (LO), which is critical to the formation and functioning of connective tissue. The reaction of oxidative deamination of specific lysine residues in the extracellular matrix initiates the formation of cross-links that stabilize newly formed elastin and collagen (Linder and Hazegh-Azam, 1996).

The role of copper in the pigmentation of the skin is related to the requirement of cuproenzyme tyrosinase (monophenol oxidase) for melanin synthesis. Mutational loss of this catalytic function leads to albinism (Arredondo and Nunez, 2005; Linder, 1991). The EFSA considers that the following wording reflects the scientific evidence: “Copper contributes to normal skin and hair pigmentation”.6

Selenium

The role of selenium as an indirect component of the antioxidant network is well established. This defense system comprises low-molecular-weight antioxidants and antioxidant enzymes like glutathione peroxidases, which catalyse the reduction of hydrogen peroxide or organic hydroperoxides using reduced glutathione as a co-substrate (Papp et al., 2007). These enzymes and other selenoenzymes, such as the thioredoxin reductases, which are also involved in antioxidant defense, are selenium-dependent and can respond to selenium supplementation. The EFSA confirms that a cause and effect relationship between the dietary intake of selenium and the protection of DNA, proteins and lipids from oxidative damage has been established. The following wording reflects the scientific evidence:“Selenium contributes to the protection of cell constituents from oxidative damage”.7

Conclusion

Due to the studies of the ingredients and the results of the clinical study for Perfect Beauty Life® Anti Aging, the conclusion can be drawn that this product helps to significantly improve skin dryness and roughness, as well as the freshness of the facial appearance. Substantial improvement was observed in skin firmness and elasticity, and also in the regularity of skin tone. It promotes a healthy skin from within and provides protection against antioxidants.8

Author: Dr. Marc Schneider (Head of Business Development); marc.schneider@aenova-group.com

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