The Science behind and mode of action of
Perfect Beauty Life® Anti Aging – Improve the signs of aged skin
– Scientific Summary –
Good nutrition plays an important role in maintaining healthy and attractive skin. Our skin is the largest organ of our body, and like any other organ it gets its nutrients through blood circulation and thus from our nutrition. For example, it plays an important role in delivering photo-protective effects to the skin.
The ageing of the skin is a continuous and visible process. Fortunately, certain ingredients in our food can slow down this ageing process to some extent. One of these is lycopene, a powerful antioxidant that gives tomatoes their natural red colour. Antioxidants are important weapons in the fight against free-radical damage, and are helpful in preventing premature skin ageing.
Perfect Beauty Life® Anti Aging is a carefully selected combination of ingredients such as evening primrose oil and the specially designed Lycolignol®-Complex. Vitamins C and E, zinc, copper and selenium complete the formulation to address the signs of ageing skin.
Clinical Study of the Perfect Beauty Life® Anti Aging
The purpose of this explorative study was to assess the efficacy of a food supplement compared to a placebo over a period of three months. Skin hydration, elasticity and sebum, as well as the structure of the collagen network and stratum corneum (SC) thickness were assessed before intake of the test product and after 6 and 12 weeks. Visual evaluation of skin dryness, roughness, redness, wrinkles, comedones and dandruff was assessed by a trained technician and facial images were taken. At the end of the study, the images were evaluated in terms of skin tone and facial appearance by lay raters. 8
71 eligible male and female subjects were enrolled, of which 60 finished the study without major protocol deviations, with a mean age of 33.0 ± 8.3 years. 8
At day 1 (Baseline) a visual evaluation was performed by a trained technician and measurement of skin hydration, elasticity and sebum was performed. Assessment of collagen network and SC thickness was performed on 40 subjects (all with visible wrinkles). Standardized images were taken and the subjects received the test product or placebo and a diary. The subjects took two capsules daily for the next three months. All assessments were repeated after 6 weeks (day 43) as well as after 12 weeks (day 85). 8
Visual evaluation was performed by a trained technician on skin dryness, skin redness, skin roughness and dandruff. For subjects with a blemish skin-lesion, a count of comedones (black and white heads) in a defined area (cheeks, forehead etc.) was performed. For subjects with visible wrinkles, an evaluation of wrinkles around the eye was performed.8
Compared to the placebo, the food supplement improved skin dryness and skin roughness significantly in group 2 of the older women. Skin firmness was also improved in this group, but just missed the significance. Regularity of skin tone by tendency was improved in the complete test group after day 43, and in group 2 of the older women by day 43. In group 1 with the younger women, assessment of photographs revealed a significant improvement of freshness in their facial appearance by day 43. By tendency this effect was also observed in the complete test group by day 43. 8
In this exploratory study, the food supplement was well tolerated. Furthermore, it was effective in improving several of the assessed skin conditions.8
The Lycolignol®-Complex is a unique high-quality blend of three ingredients. It combines special grades of flaxseed extract, green tea extract and also lycopene-rich tomato extract. It has been proven to have antioxidant properties in a human study, and protects the skin against the negative effects of free radicals.
Evening Primrose Oil
Evening Primrose Oil (EPO) contains a high amount of the omega-6 fatty acid gamma linoleic acid (GLA) which is largely responsible for the remarkable healing properties of the plant. In fact, EPO contains one of the highest concentrations known of this important substance, and only a few other plants contain it in any quantity. This makes Evening Primrose an important medicinal herb, and as studies continue the list of benefits will very likely become much longer. The gamma-linoleic acid and other nutrients in this oil are essential for cell structure and improve the elasticity of the skin.
A randomized, double-blind, placebo-controlled study in healthy adults tested the effects of EPO on skin moisture, transepidermal water loss (TEWL), redness, firmness, elasticity, fatigue resistance and roughness. All the measured variables were significantly different in the EPO group compared with the placebo. Skin moisture, TEWL, elasticity, firmness, fatigue resistance and roughness had significantly improved. The present study indicates that the regular intake of evening primrose oil with a high GLA content strengthens the physiological skin barrier function, improves biomechanical properties and smoothes the surface profile of skin. 1
A cause-and-effect relationship has been established between the dietary intake of vitamin C and normal collagen formation. The European Food Safety Authority (EFSA) considers that the following wording reflects the scientific evidence: “Vitamin C contributes to normal collagen formation and the normal function of skin.” 2
Vitamin C functions physiologically as a water-soluble antioxidant, and plays a major role as a free-radical scavenger (Sadler et al., 1999; IoM, 2000). It is part of the antioxidant defense system, which is a complex network including endogenous and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects between the various components. The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of vitamin C and the protection of DNA, proteins and lipids from oxidative damage. 2
Vitamin E is also part of the antioxidant defense system, which is a complex network including both endogenous and dietary antioxidants, antioxidant enzymes and repair mechanisms, with mutual interactions and synergetic effects among the various components. (Shils et al., 2006; IoM 2000). Reactive oxygen species (ROS) can damage molecules such as DNA, proteins and lipids if they are not intercepted by the antioxidant network, which includes free-radical scavengers such as antioxidant nutrients. The EFSA points out that a cause-and-effect relationship has been established between the dietary intake of vitamin E and protection of DNA, proteins and lipids from oxidative damage. The following wording reflects the scientific evidence: “Vitamin E contributes to the protection of cell constituents from oxidative damage”.3
Zinc plays an essential structural, regulatory or catalytic role in many enzymes. It also maintains the configuration of a number of non-enzymatic proteins, facilitates hormone and receptor binding at membrane and nuclear levels, and contributes to the integrity of bio-membranes. Consequently, zinc participates in gene expression and in the mechanism and control of major metabolic pathways involving proteins, carbohydrates, nucleic acids and lipids (SCF, 1993; DoH, 1991). Human zinc-deficiency symptoms include skin lesions such as changes in the regeneration of the skin (SCF, 2003; EVM, 2002, Cousins, 2006). The EFSA concludes that a cause-and-effect relationship has been established between the dietary intake of zinc and the maintenance of normal skin. The following wording reflects the scientific evidence: “Zinc contributes to the maintenance of normal skin” 4, and “Zinc contributes to the protection of cell constituents from oxidative damage”.5
Symptoms of severe copper deficiency include lack of collagen maturation. Copper is a cofactor of an extracellular enzyme called lysyl oxidase (LO), which is critical to the formation and functioning of connective tissue. The reaction of oxidative deamination of specific lysine residues in the extracellular matrix initiates the formation of cross-links that stabilize newly formed elastin and collagen (Linder and Hazegh-Azam, 1996).
The role of copper in the pigmentation of the skin is related to the requirement of cuproenzyme tyrosinase (monophenol oxidase) for melanin synthesis. Mutational loss of this catalytic function leads to albinism (Arredondo and Nunez, 2005; Linder, 1991). The EFSA considers that the following wording reflects the scientific evidence: “Copper contributes to normal skin and hair pigmentation”.6
The role of selenium as an indirect component of the antioxidant network is well established. This defense system comprises low-molecular-weight antioxidants and antioxidant enzymes like glutathione peroxidases, which catalyse the reduction of hydrogen peroxide or organic hydroperoxides using reduced glutathione as a co-substrate (Papp et al., 2007). These enzymes and other selenoenzymes, such as the thioredoxin reductases, which are also involved in antioxidant defense, are selenium-dependent and can respond to selenium supplementation. The EFSA confirms that a cause and effect relationship between the dietary intake of selenium and the protection of DNA, proteins and lipids from oxidative damage has been established. The following wording reflects the scientific evidence:“Selenium contributes to the protection of cell constituents from oxidative damage”.7
Due to the studies of the ingredients and the results of the clinical study for Perfect Beauty Life® Anti Aging, the conclusion can be drawn that this product helps to significantly improve skin dryness and roughness, as well as the freshness of the facial appearance. Substantial improvement was observed in skin firmness and elasticity, and also in the regularity of skin tone. It promotes a healthy skin from within and provides protection against antioxidants.8
Author: Dr. Marc Schneider (Head of Business Development); firstname.lastname@example.org
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